BENZISOTHIAZOLINONE

Benzisothiazolinone(BIT) is synthesized through the reaction of 2-mercaptobenzothiazole with sodium hydroxide and chloroacetyl chloride. In this process, the mercaptobenzothiazole is first deprotonated, creating a nucleophilic species that reacts with chloroacetyl chloride, forming the isothiazolinone structure. The resulting product is then purified, often through recrystallization or distillation, to ensure a high level of purity suitable for use in cosmetic formulations.

Benzisothiazolinone(BIT) is used in cosmetics as a preservative and biocide. It exhibits broad-spectrum antimicrobial activity against bacteria, fungi, and yeast, making it effective in various formulations, particularly those that are water-based.

It is commonly found in products like moisturizers, shampoos, makeup products, and sunscreens.