Cosmetic delivery systems generally become more effective as they get smaller, but maintaining structural stability remains a challenge. Very small carriers below 50 nm are particularly vulnerable to changes in temperature and pH levels.
The joint research team (Amorepacific and Korea Advanced Institute of Science and Technology) succeeded in developing a lipid-based delivery system with a size of about 20 nm while maintaining structural stability to improve the skin absorption of cosmetic products.
The study also used advanced analytical techniques such as cryo-electron microscopy, X-ray diffraction analysis and molecular dynamics simulations to accurately confirm the formation and stability of the nanostructure at the molecular level.
Amorepacific’s R&D center said it is focusing on triterpenoids, plant-derived compounds that enhance molecular bonding and stabilize the delivery structure.
The company said human skin tests have shown that the new technology improves the even distribution of active ingredients into deeper layers of the skin compared to conventional delivery systems. Amorepacific has named the technology “Lipo3Ex” and is currently using it in products under its IOPE and Primera brands.
Source: Amorepacific
